Jul 13, 2011
Despite of the development of new anti hypertensive agents, hypertension in elderly is still
a big health problem. Nigella sativa seed extract, derived from a small plant originating in
Middle east which can be found abundantly in Asia, has shown small antihypertensive effect
in adult. Diuretic effect of Nigella sativa is thought to be the main mechanism for the
effect but as it also shows anti-inflammatory and vasodilatory activity which are important
contributors in arterial stiffness, the main pathogenesis of hypertension in elderly, thus
it has a superior potential benefit for this population. We will conduct a randomized,
double blind, placebo-controlled trial to prove the effect of Nigella sativa seed extract in
elderly patients with hypertension. Our hypothesis is 300 mg Nigella sativa seed extract
twice daily will have anti-hypertensive effect in the blood pressure of elderly with
hypertension.
Clinical Trial Conditions: Hypertension
Treatments in this Clinical Trial : Nigella sativa
Clinical Trial Phase: Phase 3
Eligible Clinical Trial Participant Age : Between 60 years to 100 years
Can Healthy Volunteers Participate: No
Clinical Trial Lead Sponsor: Indonesia University
Detailed Clinical Trial Description: Despite of the development of new anti hypertensive agents, hypertension in elderly is still
a big health problem. Nigella sativa seed extract, derived from a small plant originating in
Middle east which can be found abundantly in Asia, has shown small antihypertensive effect
in adult. Diuretic effect of Nigella sativa is thought to be the main mechanism for the
effect but as it also shows anti-inflammatory and vasodilatory activity which are important
contributors in arterial stiffness, the main pathogenesis of hypertension in elderly, thus
it has a superior potential benefit for this population. We will conduct a randomized,
double blind, placebo-controlled trial to prove the effect of Nigella sativa seed extract in
elderly patients with hypertension. Our hypothesis is 300 mg Nigella sativa seed extract
twice daily will have anti-hypertensive effect in the blood pressure of elderly with
hypertension.
The clinical trial information was obtained from http://clinicaltrials.gov/ct2/show/NCT01393054
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