Nigella Sativa flowers

Sonntag, 15. August 2010

Nigella sativa seed extract in asthmatic patients

Keywords:asthma;Nigella sativa;pulmonary function tests;symptom score


In previous studies, the relaxant, anticholinergic (functional antagonism) antihistaminic, effects of Nigella sativa have been demonstrated on guinea-pig tracheal chains. In the present study, the prophylactic effect of boiled extract of N. sativa on asthmatic disease was examined. Twenty-nine asthmatic adults were randomly divided into control group (14 patients) and study group (15 patients), and they were studied for 3 months. In the study group 15 mL/kg of 0.1 g% boiled extract and in the control group a placebo solution was administrated daily throughout the study. Asthma symptom score, asthma severity, frequency of symptoms/week and wheezing were recorded in the beginning (first visit), 45 days after treatment (second visit), and at the end of the study (third visit). Pulmonary function tests (PFTs) were also measured, and the drug regimen of the patients was evaluated at three different visits. All asthma symptoms, frequency of asthma symptoms/week, chest wheezing, and PFT values in the study group significantly improved in the second and third visits compared with the first visit (P < 0.05 to P < 0.001). In addition, further improvement of chest wheezing and severity of disease on the third visit were observed compared with the second visit in this group (P < 0.05 for both cases). In the third visit all symptoms in the study group were significantly different from those of the control group (P < 0.01 to P < 0.001). However, in the control group, there were only small improvements in some parameters in just the second visit. The usage of inhaler and oral β-agonists, oral corticosteroid, oral theophylline and even inhaler corticosteroid in the study group decreased at the end of the study while there were no obvious changes in usage of the drugs in control subjects. The results of phase I study generally suggest a prophylactic effect of N. sativa on asthma disease and warrant further research regarding this effect.

Mittwoch, 7. Juli 2010

Black seeds anti aging properties

Zaro Agha, the 156-year-old Turk who came out of the ancient East to show the modern world what the oldest living man looks like, fell victim to modernism today [Sept. 26], and is near death. An automobile knocked him down on busy 20th-century Broadway. Physicians say his condition is critical. Agha, who came to the United States several months ago to give scientists an opportunity to marvel at him, was standing on the curb with his great-grandson, who is acting as his manager. An automobile grazed him and knocked him down, his head striking the pavement. He was taken unconscious to a drugstore and then to a hospital. The taxi driver disappeared in traffic.

Zaro Agha worked as a porter, and died in an Istanbul hospital on June 29, 1934 at the age of 164. Zaro Ağa reported in his later years that some things that may have been attributed to his long life were habit of eating yogurt, honey and black seeds on a daily basis. Agha also fathered a child at the age of 90.

There are many stories of middle eastern men retaining their vitality and libido into their later years. Habaat Sawda (Black Love, Seed) has been venerated since the ancient times in the land of Egypt and is a vital medical supplement for the majority of Middle Eastern communities.

Despite the lack of clean purified water for the average common person living in the Middle East, many people are able to extend their life's using this ancient medicine that protects the body' s internal organs and promotes overall good health.

Freitag, 2. Juli 2010

Thymoquinone and cisplatin as a therapeutic combination in lung cancer:

Kalonji – Nigella is a small black seed, grown on Kalonji bushes. This plant originated in Turkey and/or Italy and is widely grown throughout India.

Thymoquinone (TQ) is a compound extracted from Black Caraway seeds of Nigella Sativa and is active against various cancers. Cisplatin (CDDP) is the most active chemotherapeutic agent in Lung Cancer.

Here we report activity of TQ against non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cell lines alone and in combination with Cisplatin (CDDP).

Methods: For proliferation MTT assay, cell viability trypan blue assay and for apoptosis Annexin-V FITC assay were used in NCI-H460 and NCI-H146 cell lines. Inhibition of invasion by TQ was assessed using Matrigel assay and its affect on release of various cytokines was determined using RayBio Human Cytokine detection kit.

Mouse xenograft model using NCI-H460 was used to determine in vivo activity of TQ and CDDP. Inhibition of LPS induced NF-Kappa B expression by TQ was determined using transgenic mice expressing a luciferase reporter.

Results: TQ was able to inhibit cell proliferation, reduce cell viability and induce apoptosis.

TQ at 100 uM and CDDP at 5 uM inhibited cell proliferation by nearly 90% and the combination showed synergism. TQ was able to induced apoptosis in both NCI-H460 and NCI-H146 cell lines.

TQ also appears to affect the extracellular environment inhibiting invasion and reducing the production of two cytokines ENA-78 and Gro-alpha which are involved in neo-angiogenesis. Using a mouse xenograft model we were able to demonstrate that combination of TQ and CDDP was well tolerated and significantly reduced tumor volume and tumor weight without additional toxicity to the mice.

In the combination arms (TQ5mg/kg/Cis 2.5mg/kg) tumor volume was reduced by 59% and (TQ20mg/kg /Cis 2.5mg/kg) by 79% as compared to control which is consistent with in vitro data. TQ down regulated NF-Kappa-B expression which may explain its various cellular activities and this activity may prove useful in overcoming CDDP resistance from over expression of NF-Kappa-B.

Conclusion: Thus TQ and CDDP appear to be an active therapeutic combination in lung cancer.

Author: Syed JafriJonathan GlassRunhua ShiSonglin ZhangMisty PrinceHeather Kleiner-Hancock

Credits/Source: Journal of Experimental &Clinical Cancer Research 2010, 29:87

Sonntag, 27. Juni 2010

Further benefits of black seed

Strengthening the Immune System

Nigella sativa (Black Seed) can increase the number of T cells either to increase natural killer cells. Effectiveness up to 72% when compared with placebo only 7%. Thus, taking Black Seed can boost the immune system. In 1993, DR. Basil Ali with his colleagues from the College of Medicine at the University of King Faisal Saud Pharmasetik publish in the journal. Black Seed extract capabilities are recognized Prof. G Reitmuller, Director of the Institute Immonologi from the University of Munich, can boost the immune system and can be used bioregulator. Thus, Black Seed can be used as a cure for diseases that attack the immune system, such as cancer and AIDS.

Improve memory, concentration, and alertness

With the content of linoleic acid (omega 6) and linoleic acid (omega 3), Black Seed is the nutrition for the brain cells to improve memory and intelligence. Black Seed also improve micro (blood circulation) to the brain and is very appropriate given the child’s age and growth of the elderly.

Increasing hormone bioactivity

Hormones are active substance which is produced by endocrine glands into the blood circulation. In the human body there are many different types of hormones on reproductive hormones ataranya associated with sexual arousal. Black Seed is one setrol content that serves as hormone synthesis and bioactivity.

Neutralize toxins in the body

Toxins may interfere with its metabolism and decrease the function of important organs like liver, lungs and brain. Symptoms of mild poisoning may include diarrhea, vomiting, dizziness, respiratory problems and reduce the power of concentration. Black Seed contains saponins that can neutralize and clean up toxins in the body.

Overcome sleep disorders and stress

Sapion contained in Black Seed has functions such as corticosteroids that can influence carbohydrate, protein and fat and also affects the functioning of the heart, kidneys, muscles and nerves. Sapion serves to defend itself from environmental changes, sleep disturbances and can relieve stress.


Histamine is a substance released by bodily tissues, providing an allergic reaction such as bronchial asthma. Black Seed Oil is made from ‘can isolate dithimoquinone. This oil is often called volatile nigellone from nigella. Granting of this oil had a positive impact penderta bronchial asthma.

Research conducted by Nirmal Chakravaty MD in 1993 proved the crystals from negelone suppresive effect. These crystals can be inhibited protemkinasi C, a substance that triggers the release of histamine.

Other research also proves the same thing. This time it was done by Dr. Med. Peter Schleincher, immonologi experts from the University of Munich. Those who do test on 600 people who suffer from allergies. The results were quite convincing, 70% who suffer from dust allergies, pollen, acne and asthma recovered after being given a nigella oil (Black Seed). In practice Dr. Black Seed Schleincher prescribe ‘to patients suffering from influenza.

Improve the digestive tract and anti-bacterial

Black Seed oil contains the essential oil from a known volatif useful for improving digestion. Essential oil traditionally used to cure diarrhea. In 1992, Pakistan Journal of Pharmaceutical create a result that proves more potent volatile oils to kill strains of bacteria such as Cholera and E. Coli V compared with antibiotics such as tetracycline and ampicilin.

Breast milk launched

The combination of unsaturated fat and hormonoal structure contained in Black Seed oil ‘may launch breast milk. This research was later published in the research literature Potchetstroom University in 1989.

Supplementary nutrition to pregnant women and toddlers

In infancy, children need to improve isstem nutrusi naturally immune, especially during the rainy season is very easy to children with flu and colds. The content of Omega 3, Omega 6 and Omega 9 which are on the nutrients Habbatussauda’merupakan assist in the development of brain tissue.

Rejuvenate skin cells and delay the aging process

The skin is the outermost one of the important organs. Its function is to protect the body from a physical clash, bacteria and fungi. Black Seed is very good to maintain moisture, smoothness and youthfulness of skin.

Nutrition for the elderly and food supplement.
Rich in nutrients as additional energy is ideal for people who are elderly, especially to keep the immune system and brain cells revitalitas quickly so as not senile. Black Seed contains 15 kinds of compiler zest acid contents of protein, including the nine essential amino acids. Amino acids can not be produced by the body in sufficient quantity, and therefore must be obtained from food.

The principles of anti-tumor at the International Cancer Congress in New Delhi on last fall, Black Seed Oil ‘was introduced Immonobiologi cancer scientists from the Laboratory of South Carolina. Black Seed stimulates bone marrow and immune cells. Interferonnya produce normal cells against harmful viruses as well as destroy tumor cells and enhancing antibodies.

Dienstag, 9. März 2010


COREVITPLUS contains the most powerful extracts, berries and specially Black Cumin seed oil, which is exhibited as one of the highest total antioxidant values among plant oils based on ORAC measurement.

Product Benefits and Contents:

Circulatory System

· Helps reduce the amount of bad cholesterol clogging the walls of arteries while increasing the level of good cholesterol in the system.

· Purifies the blood and improves circulation.

· Enhances the production of red and white blood cells.

· Strengthens the heart and alleviates heart palpitations.

· Helps reduce plaque build-up in the arteries.

· Maintains healthy blood pressure and blood sugar.

· Increases blood flow and fights off free radicals.

· Helps reduce the risk of heart disease.

Respiratory System

· Reduces the risk of having respiratory conditions like bronchitis, asthma and emphysema.

Digestive System

· Helps slow the digestive processes to feel full longer.

· Protects against digestive infections.

· Helps lower cholesterol levels.

· Helps improve appetite.

· Prevents liver failure.

· Disrupts the development of kidney stone formation.

· Reduces gum problem.

· Prevents mouth sore.

· Improves the health of the colon epithelial lining.

· Helps keep metabolic rate high, which in turn burns fat.

Integumentary System

· Protects the skin from ultraviolet damage and repairs skin damaged by the sun.

· Helps improve your complexion, remove dead skin and diminish wrinkles.

· Helps combat skin ulcers on the legs.

Nervous System

· Boosts enzymes that grow new nerve cells in the brain and protects the brain from oxidative stress and Alzheimer’s or dementia.

Visual System

· Strengthens the walls of blood vessels and improves blood flow through the small vessels that deal with the health of the eyes and can improve vision.

Immune System

· Helps the body fight viruses, allergens and carcinogens.

· Strengthens and maintains the immune system in and out and greatly reduces the possibility of developing any infection.

· Reduces stress.

· Boosts energy levels.

· Helps prevent cancer.

Endocrine System

· Protects the body from premature aging by increasing Vitamin C levels in the cells and scavenging for toxins so the organs can get rid of them.

· Helps slow the aging process in both body and brain.

· Helps in weight loss.

· Relieves insomnia and promotes restful sleep.

· Relieves back pain & muscle spasms.

· Helps protect the body tissue from oxygen-related damage.

Skeletal System

· Helps improve bone structure.

Reproductive System

· Slows growth of prostate cancer.

· Relieves fibrocystic diseases and painful menstruation.

· Improves sex life.

Black Cumin

A seed derived from a plant with botanical name Nigella sativa used as a nutritional supplement. It reduces the risk of having respiratory conditions like bronchitis, asthma and emphysema. It is widely used as a general tonic to boost immune system and helps prevent cancer.

Acai Berry

Known for its deep purple color, as well as for being a rich source of many important antioxidant vitamins. A fruit with high-ORAC value that helps slow the aging process in both body and brain.


An aggregate fruit that is composed of many smaller fruits called drupes. It contains ellagic acid, an antioxidant that has shown to protect the skin from ultraviolet damage and repairs skin damaged by the sun.


A berry full of nutrients and flavor, yet very low in calories. It boosts enzymes that grow new nerve cells in the brain and protects the brain from oxidative stress and Alzheimer’s or dementia.


A relatively small, red berry which grows on low-hanging vines in temperate zones. It contains flavonoids that help reduce the amount of bad cholesterol clogging the walls of arteries while increasing the level of good cholesterol in the system.


Composed of many seed-containing fruit sections called drupelets. It is packed with fiber that helps slow the digestive processes to feel full longer and manganese, a trace mineral that helps keep metabolic rate high, which in turn burns fat.


A delicious and nutrition-rich red colored berry. It is a rich source of many health promoting phyto-nutrients, minerals and vitamins that are essential for optimum health. It has potential health benefits against cancer, aging, inflammation and neurological diseases.

Bilberry Extract

Derived from the bilberry plant – containing edible berries. It strengthens the walls of blood vessels and improves blood flow through the small vessels that deal with the health of the eyes and can improve vision.

Grapeseed Extract

Contains a vast array of health-giving ingredients such as protein, lipids, carbohydrates and bioflavonoids. It helps the body fight viruses, allergens and carcinogens. It protects the body from premature aging by increasing Vitamin C levels in the cells and scavenging for toxins so the organs can get rid of them.

Green Tea Leaf Extract

Rich in antioxidant that protects against digestive and respiratory infections and helps lower cholesterol levels. It also helps reduce the risk of heart disease, cancer and prevents liver failure.

Mangosteen Fruit Extract

Strengthens the immune system in and out and greatly reduces the possibility of developing any infection. It helps improve appetite, bone structure, skin condition, purifies the blood and improves circulation in addition to strengthening the heart.

Noni Fruit Extract

An antioxidant and is rich in Vitamin C. It helps reduce asthma, flu and skin infection which is caused by bacteria. It also strengthens the heart and alleviates heart palpitations. It cleans the blood, builds the immune system and used as a treatment for bladder infections, diabetes, colds and constipation.

Pomegranate Fruit Extract

Contains a high level of antioxidants and contains many vitamins and minerals which helps reduce plaque build-up in the arteries. It lowers cholesterol, slows growth of prostate cancer, increases blood flow and fights off free radicals.

Wolfberry Fruit Extract

Also called red fruit or eye-clearing fruit. It maintains healthy immune system, improving eye conditions, supports healthy liver function and maintains healthy blood pressure and blood sugar.

Where to buy Black seed oil


Nigella Seeds, or Black Cummin.

Agrostemma githagoNigella damascenaNigella sativaBy DR. F. A. FLÜCKIGER, Professor in the University of Bern.

These seeds, which had a place in the Bengal Pharmacopoeia (1844), are included in the Pharmacopoeia of India (1868) among the "non-officinal" articles. But, as they are still of considerable importance in the East, and are even in use in some parts of Europe, I have thought that a few particulars regarding the experiments I have made upon them may not be uninteresting to the readers of the Pharmaceutical Journal.

Name.—In pharmacy they have been termed Semen Nigellae, s. Melanthii, s. Cumini nigri. In English the plant bears the name of Nigella, Black Cummin, Gith, or Bishopswort; in German the seeds are called Schwarzkümmel or Nardensame; in French Cumin noir, Graine de Nigelle romaine, or Poivrette. Most of the Indian names signify, when translated, Black Cummin.

Botanical Origin.—Nigella sativa, L. (N. indica, Roxb.), belongs to the Order Ranunculaceae and is an annual herb, 8 to 12 inches high, with leaves cut into numerous, narrow, pinnate segments. The flowers are solitary, terminal, without an involucre; the petals blue and white, with greenish glands. The capsule is formed of 3 to 6 carpels, opening by the ventral suture. The plant grows on the Mediterranean coasts, in Egypt and Trans-Caucasia, whence it has spread to India. Boissier (Flora Orientalis, i, 68.) regards the var. β brackyloba, occurring in Cilicia and Syria, as the original type of the plant in a wild state.

Nigella sativa is now widely distributed as a corn-field weed throughout temperate Europe and America, (Though occasionally cultivated in gardens, the plant is scarcely naturalized in the United States.—EDITOR AMER. JOUR. PHARM.) though not in Britain. In Germany it is cultivated to some extent near Erfurt.

History.—Nigella is thought by some to be the kezach of Isaiah (xxviii, 25), translated in the English Bible fitches.

Dioscorides described the plant clearly under the name of Mελανθιον. Pliny called it Git, under which appellation it is found among the plants which Charlemagne ordered to be cultivated on the imperial farms of his dominions. This name, however, was frequently applied in the middle ages to the Corn Cockle, Agrostemma Githago, L., which is, indeed, termed by Gerarde Bastard Nigella. In his time, nigella was commonly sown in gardens, the seeds being used medicinally in wine as a spicy stimulant, and also as a perfume, for he says "it serveth well among other sweets to put into sweet waters, bagges, and odoriferous powders."

Nigella seeds had a place in the London Pharmacopoeia as late as the edition of 1721. In the East, the seeds have been extensively used from the remotest times to the present day.

Description.—The seeds are about 1/16th of an inch long, of an irregular, compressed pyramidal form, 3 or 4-sided, with an oblique rounded base, whence sharp ridges proceed towards the blunt summit of the seed. The surface is black, rough, granular, and devoid of polish. The seeds have an aromatic taste, and, when crushed, considerable fragrance. (* Those of the nearly allied N. Damascena, L., are rather more ovoid, less sharply ridged, less aromatic, and not pungent.)

Microscopical Structure.—The albumen consists of large polyhedral cells, and is covered by a thin brown tegmen. The testa presents two or three rows of more or less thick-walled cells, the inner being elongated in a direction parallel to the surface of the seed, the outer vaulted, and a certain number of them, chiefly those forming the ridges, prominently conical. The whole testa is blackish or dark bluish. The embryo is situated near the apex of the seed.

The tissue of the albumen abounds in fat oil and in granular albuminous matters; it is not altered by a salt of iron.

Chemical Composition.—Reinsch in 1841 obtained from this seed 35.8 per cent. of fat oil, 0.8 per cent of volatile oil, and only 0.6 per cent. of ash. He gave the name of Nigellin to a bitter extract resembling turpentine, yet soluble in water as well as in alcohol, though not in ether.

By submitting 25 lbs. of fresh seed to distillation, I obtained a nearly colorless essential oil in even smaller quantity than Reinsch. It has a slight odor, somewhat resembling that of parsley oil, with a magnificant bluish fluorescence, as already remarked by Reinsch.

In a column 50 mm. long, this oil deviates the ray of polarized light 9.8° to the left. Its specific gravity is 0.8909. The chief part of it, when distilled with chloride of calcium in a current of dry carbonic acid, comes over at 493° (256° C.) In an elementary analysis (Performed in my laboratory by Dr. Kraushaar.) it yielded: carbon 83.3, and hydrogen 11.8 per cent, corresponding to the formula, 2C10H16+H2O.

The residual portion was almost entirely devoid of deviating power; it yielded: carbon 87.89, and hydrogen 11.72 per cent., after having been rectified by means of sodium. This part of the oil consequently belongs to the formula C10H16.

I extracted the fat oil, by means of boiling ether, from seed grown in Germany, previously finely powdered. The oil thus obtained, which necessarily included some essential oil, imparting to the other its fluorescence, amounted to 25.6 per cent. It is a fluid fat, which does not congeal at + 5° (-15 °C.); it was found to consist chiefly of olein, besides which it yielded a considerable amount of a solid fatty acid, the crystals of which, after reiterated purification, melted at 131° (55° C.) The melting point did not rise by recrystallization, the acid being probably a mixture of palmitinic and myristic acids.

Nigella seeds, powdered and dried over sulphuric acid, yielded 3.3195 (On an average of three experiments made in my laboratory.) per cent. of nitrogen, answering to about 21 1/2 per cent. of albuminous matter.

Uses.—It is stated in the Pharmacopoeia of India, that nigella seeds are carminative, and they were formerly so regarded in Europe. In the East generally they are used as a condiment to food, and in Greece, Turkey and Egypt they are frequently strewed over the surface of bread and cakes in the same manner as anise or sesame. The fixed oil of the seeds is also expressed for use.

I have no recent statistics indicating the extent to which the seed is grown, but may state, on the authority of an official French document that, during the year 1854-55, 83 quarters, worth 2592 rupees, were exported from Madras to Ceylon.—Pharm. Journ., Lond., Aug. 26, 1871.

Where to buy Black seed oil

Black seed a cure all

It is important to note that black seed should be taken everyday of your life as is water or bread. Then when you get any disease it is easily cured. The normal daily routine should be one t. of oil mixed with juice or honey. If a person is sick then the dosage should be doubled.

A great many people go wrong by taking more nigella sativa as thinking it is needed. More is not better. What I take is oil once a day and the regular seeds ground mixed with honey once a day. It is absolutely delicious.

A woman had cancer and she did the above and added garlic mixed with honey also and was cured of cancer in 4 months. As I cannot give medical advice, I can only tell you what others have done.

Nigella Sativa is a prophetic cure sent from God with the revelation that it cures all disease except death. My general feeling is first you must believe in the cure and then thank God because he cured you.

There are many brands on the market stay away from anything stating it s caraway. At the top of the forum are some suggested sites.


Where to buy Black seed oil

Thymoquinone a tumour breakthrough.

Thymoquinone, a potential therapeutic agent of Nigella sativa, binds to site I of human serum albumin

G. Lupidia, 1, A. Scireb, 1, E. Camaionic, K.H. Khalifea, G. De Sanctisa, F. Tanfanib and E. Damianib, ,

a Dipartimento di Biologia M.C.A., Università degli Studi di Camerino, Camerino, Italy

b Dipartimento di Biochimica, Biologia e Genetica, Università Politecnica delle Marche, Ancona, Italy

c Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Perugia, Italy

Available online 18 February 2010.


Thymoquinone (TQ) is the main constituent of Nigella sativa essential oil which shows promising in vitro and in vivo antineoplastic growth inhibition against various tumour cell lines. Because of the increasing interest to test it in pre-clinical and clinical researches for assessing its health benefits, we here evaluate the interactions between TQ and human serum albumin (HSA), a possible carrier of this drug in vivo. Binding to HSA was studied using different spectroscopic techniques. Fourier transform infrared (FT-IR) and circular dichroism (CD) spectroscopies suggest that the association between TQ and HSA does not affect the secondary structure of HSA. Using fluorescence spectroscopy, one mole of TQ was found to bind one mole of HSA with a binding constant of 2.39 ± 0.2 104 M−1. At 25 °C (pH 7.4), van’t Hoff’s enthalpy and entropy that accompany the binding were found to be −10.24 kJ/mol−1 and 45 J/mol−1K−1 respectively. The thermodynamic analysis of the TQ-HSA complex formation shows that the binding process is enthalpy driven and spontaneous, and that hydrophobic interactions are the predominant intermolecular forces stabilizing the complex. Furthermore, displacement experiments using warfarin and ibuprofen indicate that TQ could bind to site I of HSA, which is also in agreement with the results of the molecular modeling study.

Keywords: Thymoquinone; Nigella sativa; Human serum albumin; Drug-protein complex; FT-IR; Fluorescence quenching; Circular dichroism; Molecular docking

Abbreviations: TQ, thymoquinone; DHTQ, dihydrothymoquinone; DHTQ-GS, glutathionyl-dihydrothymoquinone; HSA, Human serum albumin; CD, Circular Dichroism; FT-IR, Fourier transform infrared; GSH, glutathione; NADH, nicotinamide adenine dinucleotide reduced form; NADPH, nicotinamide adenine dinucleotide phosphate reduced form.

Where to buy Black seed oil

Dienstag, 23. Februar 2010

Alzheimer and cardiovascular Disease.

Head researcher, Prof. Dr. Maznah Ismail said the product is extracted from Nigella sativa seeds containing Thymoquinone (TQ) that has a very high anti-oxidant activity thus the capacity to maintain optimum health.
> Alzheimer > BioScience > Bird Communication > cardiovascular disease > Corporate Strategy > Disease > Thymoquinone > Thymoquinone Rich Fraction > TQRF > vascular disease“Cardiovascular diseases are the most common cause of death worldwide and have been associated with Alzheimer’s disease,” she said during a press conference organized by the University Research Management Centre and the Corporate Communication Division to introduce UPM New Products.
She said TQRF project was initiated since 2005 till 2008 and it works by regulating the cholesterol by a suppression that inhibits the synthesis of cholesterol.

“TQRF is extracted from Nigella Sativa seeds using an efficient and clean platform technology-Supercritical Fluid Extraction System (SFE)" said she, who is also assisted by co-researchers, Ghanya Al-Naqeeb and Norsharina Ismail from the Institure of Bioscience.

Prof. Dr. Maznah, who is also the Head of Molecular Biomedicine Laboratory, Institute of Bioscience, UPM said the reason of choosing Nigella Sativa seeds specially from Yemen, Iran and Sudan is because the TQ oil produced 40% more than the seeds from India and Sri Lanka.

She added that products currently available in the market prepared using technology are not capable of trapping TQ.

In addition, Deputy Vice Chancellor (Research and Innovation), Prof. Dato’ Dr. Abu Bakar Salleh said the product has great potentials to attract pharmaceutical companies.

“The technology is still at pre-commercialization stage and needs a clinical trial to human before it can be fully commercialized,” he added.

Patented in 2008, the product has received numerous accolades at the International Exhibition of Ideas Inventions New Products (iENA) 2009 in Nuremberg, German, two silver medals at the Malaysian Technology Expo (MTE) 2008 and 2009 and another three medals from UPM.

News by Section of Media, Publicity and Publication, Corporate Communication Division UPM (Noor Eszereen Juferi 03-89466013)

UPM Scientists Discovered Alzheimer and Cardiovascular Disease Prevention

next article 08.02.2010

A group of Universiti Putra Malaysia (UPM) researchers successfully created a product called, Thymoquinone Rich Fraction (TQRF) an agent to aid the treatment of Alzheimer and cardiovascular Disease.
Where to buy Black seed oil

Diabetes research, Canada

Antidiabetic Activity of Nigella sativa Seed Extract in Cultured Pancreatic β-cells, Skeletal Muscle Cells, and Adipocytes *

Authors: Ali Benhaddou-Andaloussi † ab; Louis C. Martineau † ab; Danielle Spoor ab; Tri Vuong ab; Charles Leduc a; Erik Joly bc; Andrew Burt d; Bouchra Meddah ae; Abdellatif Settaf e; John T. Arnason d; Marc Prentki bc; Pierre S. Haddad ab

Affiliations: a Department of Pharmacology, Universit de Montral, Montreal, and Nutraceuticals and Functional Foods Institute, Universit Laval, Quebec City, Quebec, Canada

b Montreal Diabetes Research Center, Montreal, Quebec, Canada

c Centre Hospitalier de l'Universit de Montral, Universit de Montral, Montreal, Quebec, Canada

d Department of Biology and Center for Research in Biopharmaceuticals and Biotechnology, University of Ottawa, Ottawa, Ontario, Canada

e Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco


The seeds of Nigella sativa L. (NS), a plant of the Runanculaceae family, are used in traditional medicine in North Africa and the Middle East for the treatment of diabetes. Despite widespread use and a number of scientific studies, the target tissues and cellular mechanisms of action of this plant product are not well understood. This study evaluated the effects of NS seed crude ethanol extract on insulin secretion in INS832/13 and β TC-tet lines of pancreatic β-cells and on glucose disposal by C2C12 skeletal muscle cells and 3T3-L1 adipocytes. An 18-h treatment with NS amplified glucose-stimulated insulin secretion by more than 35% without affecting sensitivity to glucose. NS treatment also accelerated β-cell proliferation. An 18-h treatment with NS increased basal glucose uptake by 55% (equivalent to approximately two-fold the effect of 100 nM insulin) in muscle cells and approximately by 400% (equal to the effect of 100 nM insulin) in adipocytes; this effect was perfectly additive to that of insulin in adipocytes. Finally, NS treatment of pre-adipocytes undergoing differentiation accelerated triglyceride accumulation comparably with treatment with 10 μ M rosiglitazone. It is concluded that the well-documented in vivo antihyperglycemic effects of NS seed extract are attributable to a combination of therapeutically relevant insulinotropic and insulin-like properties.

*Dedicated to Professor John Thor Arnason of the University of Ottawa, Department of Biology, on the occasion of his sixtieth birthday.

Keywords: Glucose uptake; insulin secretion; natural health products; traditional medicine; type 2 diabetes mellitus

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Acne Treatment

A Home Remedy for Acne – Nigella 22/02/10 Posted By: Acne Treatment Contributor

The nigella sativa, also known as the fennel flower, is a plant that has been cultivated for thousands of years and is used for medicinal purposes as a home remedy for acne and also as a spice. The plant is native of southwest Asia. For many years western civilisations have been unaware of its significance but it is now beginning to gain some recognition.

How Does Nigella Make a Good Home Remedy For Acne?

Nigella possesses an enermous number of properties and more than 200 types of complex chemical compounds such as alanine, cystine, glycine, linolenic-acid and potassium. It also has many properties that make it an effective home remedy for acne – it is antimicrobial, anti-inflammatorym analgesic, antipyretics and antineoplastic.

Nigella can also strengthen the immune system which is another way in which it is useful as a home remedy for acne. When the immune system is weak, the oil producing sebaceous glands and hair follicles within the skin are stimulated and become inflamed which causes an excess of sebum to be produced. Excessive sebum clogs the hair follicles which causes the acne breakout.

How to use Nigella as a Home Remedy For Acne

It is possible to buy nigella seeds in their natural form from an organic store and you can use these in cooking but you may need to get a little creative with your recipes as it is not really an everyday ingredient in western diets!

Perhaps a better way to use nigella as a home remedy for acne is to buy a good quality Nigella Sativa Oil as this contains all of the active ingredients of the seeds. Some brands of this oil also have other ingredients that are beneficial to your health such as omega 6 and omega 3.

Stir one teaspoon of the nigella oil into a bowl of very hot water and then hold your head over the bowl with a towel covering your head and the bowl. This will cause steam to rise which opens up the pores of the skin. The oil vaporizes and impregnates the skin through the open pores. Continue with this facial steam for around 15 minutes or as long as the steam continues to rise and then wash the face with cool water.

Where to buy Black seed oil

Sonntag, 21. Februar 2010

Cure All

The Oil That Can Change Your Life!

It is very rare that something comes along that can, by itself, change our lives. However, we would like to introduce you to a very special supplement - a pure, virgin, cold-pressed oil that can have a startling impact not just for your skin, but for virtually every aspect of your health.

Nigella Sativa Oil is possibly the most potent of all dietary supplements known to scientists. It contains over 100 known therapeutic compounds - a host of powerful agents that boost the body's immune system and impact our health in a way that no other supplement can.

The action of Nigella Sativa Oil has to be seen to be believed. Although it has been tradionally used for centuries in Asia to treat so many health problems, it is only in the last few decades that scientists have begun to take notice and investigate the incredible claims in controlled, clinical studies.

There are now over 200 independent published research papers confirming that Nigella Sativa Oil is really the closest thing known to a cure-all. The oil has been shown to exhibit the following qualities:

Analgesic: Relieves or dampens sensation of pain.

Anthelmintic: (Also know as vermicide or vermifuge.) Destroys and expels intestinal worms.

Anti-bacterial: Destroys or inhibits the growth of destructive bacteria.

Anti-Inflammatory: Reduces inflammation.

Anti-Microbial: Destroys or inhibits the growth of destructive microorganisms.

Antioxidant: Prevents or delays the damaging oxidisation of the body's cells - particularly useful against free radicals.

Anti-Pyretic: (Also known as ferbrifuge.) Exhibits a 'cooling action', useful in fever reduction.

Anti-spasmodic: Prevents or eases muscle spasms and cramps.

Anti-tumour: Counteracts or prevents the formation of malignant tumours

Carminative: Stimulates digestion and induces the expulsion of gas from the stomach and the intestines.

Diaphoretic: Induces perspiration during fever to cool and stimulate the release of toxins.

Diuretic: Stimulates urination to relieve bloating and rid the body of any excess water.

Digestive: Stimulates bile and aids in the digestive process.

Emmenagogue: Stimulates menstrual flow and activity.

Galactogogue: Stimulates the action of milk in new mothers.

Hypotensive: Reduces excess blood pressure.

Immunomodulator: Suppresses or strengthens immune system activity as needed for optimum balance.

Laxative: Causes looseness or relaxation of the bowels.

For more information on Nigella Sativa and details of published research, please see Nigella Sativa Research

Just look at what just a few people who have tried it are saying:

"This oil is simply amazing! I have not found a herb that clears the lymphatics and intestines so clearly and in such a gentle way."

A Pouget, Medical Herbalist

"I suffer from eczema. When it comes out I use your oil and it clears up very quickly."

Abdullah, Cyprus

"I had a flare up and your Nigella Sativa oil cleared it. Amazing!"

D Roper , London
Nigella Sativa comes from the Ranunculaceae,The Buttercup Family

There are around 1800 species in this family, which is found mainly in the colder regions of the world. Most of them are well-known wild flowers or garden flowers, including Buttercups, Anemones, Delphiniums, Aquilegias and Clematis. Some species, particularly Aconitum, are poisonous. Nearly all members of the family are herbaceous, with Clematis being the only woody species.

Nigella seeds are small, matte-black grains with a rough surface and an oily white interior. They are roughly triangulate, 1 1/2 - 3 mm (1/16 to 1/8 in ) long. They are similar to onion seeds.

Relatives to Nigella sativa are Nigella arvensis, Nigella ciliaris, Nigella damascena, Nigella hispanica, Nigella integrifolia, Nigella nigellastrum, Nigella orientalis. The Nigella sativa seed is used as a spice. Nigella sativa has a pungent bitter taste and smell. It is used primarily in confectionary and foods.


Diabetes Nutritional Supplements May Help Control Blood Sugar Levels
Dealing with diabetes can be controlled with correct food supplements, with proper diet and regular physical activity.

There are special additions that have been demonstrated in laboratory tests in order to stabilize blood sugar levels. Some of these supplements for diabetes are enzymes that aid digestion or improve glucose metabolism. Others are minerals such as calcium, magnesium and chromium, which are often lacking in the diet are. And other herbs and vegetables.

Herbs and vegetables has long been used by aborigines for the treatment of various diseases and symptoms. Sometimes these drugs are very effective. You can somewhat 'controversial and should not be expected that the position of the modern take drugs, but to integrate them "modern medical treatments. In someCases, people who begin taking herbal remedies are able to reduce their medication, of course, with the advice of his doctor. The herbs and herbal ingredients are included in some supplements for diabetes, because they have been historically used to treat the condition and why the modern evaluation has shown that they are to manage the condition, today may be useful.

Banaba is in some of the best diabetes supplements found. This is a plant that is native to southern Asia and has a history of traditionused to help people control their blood glucose levels. Laboratory tests have shown that lowering Banaba added in the diet of diabetic rats glucose levels in the blood and the leaves seem to contribute to weight loss in obese mice. Studies in 1999 and 2001 found that the extract of Banaba can help control blood sugar levels and possibly help you lose weight. Researchers have suggested that clinical trials that a people "true" that were in order. But clinical are quite expensive and most are sponsored by pharmaceutical companies. Most pharmaceutical companies have no interest in a natural substance, such as extract of Banaba, because it can not be patented. Therefore, clinical studies have never been, but Banaba extract has been launched in some dietary supplements for the treatment of diabetes were found.

Bitter Melon is another plant that has shown promise in the laboratory. Bitter melon tea is still used today in the Philippines, especially among the poor, in order to maintain control> The levels of blood sugar. In Ayurvedic medicine, practiced throughout the world in India and different countries, it is recommended as one of diabetes, dietary supplements and as a complement to other forms of treatment. Glycemic control should be carefully monitored when diabetic food supplement containing bitter melon in order to avoid a dangerous drop in blood sugar.

Black or Nigella sativa seed extract is used as a cure all in some countries. ModernResearch on black extract in the treatment of diabetes is temporary. But research shows so far that can reduce high blood sugar and increase the antioxidant activity, possibly preventing the complications of uncontrolled diabetes type II. Referred for further and more detailed information about this plant and other natural supplements for diabetes, please visit the Diabetes Information Guide.

Where to buy Black seed oil

Research on Intestines

Effects of Nigella sativa Seeds on Intestinal Smooth Muscle
Author: Mahmoud B. Aqel a
Affiliation: a College of Medicine, The University of Jordan, Amman, Jordan

DOI: 10.3109/13880209309082918
Publication Frequency: 12 issues per year
Published in: Pharmaceutical Biology, Volume 31, Issue 1 1993 , pages 55 - 60
Subject: Natural Products;
Formats available: PDF (English)
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The spasmolytic effects of an ethanol extract and the volatile oil of Nigella sativa seeds were tested in vitro using isolated segments of rabbit jejunum. The ethanol extract and volatile oil inhibited spontaneous movements of the rabbit jejunum. Also, the volatile oil inhibited contractions of the rabbit jejunum which were induced by high potasium (K+) solution or acetylcholine. This inhibition was dose-dependent, reversible and not affected by the addition of calcium to the organ bath. These data suggest that the plant seed has an antispasmodic effect, possibly due to a calcium antagonistic activity.

Where to buy Black seed oil

Cure of worms in dogs

Title: Prevalence and therapy of ancylostomiasis in dogs with Nigella sativa (Kalongi) and Saussurea lappa (Qust-e-shireen).
Personal Authors: Jahangir, M., Maqbool, A., Tanveer, A., Mahfooz, A.
Author Affiliation: Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan.
Editors: No editors
Document Title: Haryana Veterinarian

In first part of this study, 250 dogs in Pakistan were examined for the presence of ancylostomiasis [date not given]. Faecal examination confirmed ancylostomiasis in 67 (26.8%) dogs. A higher prevalence was noticed in puppies than in adults. In 8 controlled experiments, 48 dogs were used to compare the efficacy of Nigella sativa seeds, Saussurea lappa roots and pyrantel pamoate against Ancylostoma spp. Efficacy was quantified by determining the difference of eggs per gram of faeces (EPG) during pre- and posttreatment. It was shown that N. sativa seeds, after a single dose of 250, 300 and 500 mg/kg body weight, reduced EPG by 62.9, 80.9 and 89.6%, respectively. S. lappa roots at of 200, 250 and 300 mg/kg body weight was 40.5, 66.5 and 79.9% effective against Ancylostoma, respectively, while pyrantel pamoate at 10 mg/kg body weight was 100% effective. The efficacy order was pyrantel pamoate>N. sativa>S. lappa. No side effects were caused by any of the drugs of plant origin.

Publisher: College of Veterinary Sciences, Haryana Agricultural University

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CAB Abstracts is a unique and informative resource covering everything from Agriculture to Entomology Public Health. In April 2006 we published our 5 millionth abstract, making it the largest and most comprehensive abstracts database in its field.

Where to buy Black seed oil

Black seed oil can help pancreatic cancer

Wellness Watch/Energy Times June 2009

Herb May Inhibit Pancreatic Cancer
The fact that this disease tends to kill so quickly after diagnosis makes cancer of the pancreas difficult to study compared with other malignancies. It is generally found only after it has spread to other organs; scientists are currently trying to find the genetic clues that would allow earlier diagnosis.
The risk of developing pancreatic cancer is somewhat greater among people with a family history of the disease or an inflammatory condition called chronic pancreatitis. But an extract taken from Nigella sativa, the "black seed" used widely in Middle Eastern cooking and traditional healing, has lowered levels of the inflammatory substances linked to pancreatic cancer. Scientists at the Kimmel Cancer Center at Thomas Jefferson University found that thymoquinone, found in black seed oil, was also able to shrink tumors in 67% in animals. These findings were presented at the American Association for Cancer Research's 2009 annual meeting.

Black seed is available in two blends at

This blog contains material intended for informational purposes only. The statements made have not been evaluated nor approved by the FDA. Any dietary changes and/or product(s) mentioned should not be used to diagnose, treat, cure or prevent disease. Consult your health care provider before making changes to your health care regimen - particularly if you are taking medication(s), are pregnant, trying to get pregnant, nursing, or if you have any other health condition - before making any dietary changes, using any products mentioned or applying any information contained herein.